Effect of exercise interventions on perceived fatigue in people with multiple sclerosis: synthesis of meta-analytic reviews

摘要

Although exercise training has been advocated as a nonpharmacological treatment for\udmultiple sclerosis (MS) related fatigue, no consensus exists regarding its effectiveness. To\udaddress this, we collated meta-analytic reviews that explored the effectiveness of exercise\udtraining for the treatment of MS-related fatigue. We searched five online databases for\udrelevant reviews, published since 2005, and identified 172 records. Five reviews were\udretained for systematic extraction of information and evidence quality analysis. Although\udour review synthesis indicated that exercise training interventions have a moderate effect\udon fatigue reduction in people with MS, no clear insight was obtained regarding the relative\udeffectiveness of specific types or modes of exercise intervention. Moreover, Grading of\udRecommendation Assessment, Development and Evaluation revealed that the overall\udquality of evidence emanating from these five reviews was ‘very low’.